Sentence examples for explained by the variant from inspiring English sources
Effect sizes vary from 0 to 1, with 1 meaning that the phenotype is completely explained by the variant.
International collaborative work is currently ongoing to address this within BioGenoMEL (www.biogenomel.eu), but the study may prove inconclusive given the small proportion of the variance in 25-hydroxyvitamin D2/D3 levels explained by the variant gene.
This is due to a few variants; in Caucasians, most inter-individual variation in function is explained by the variant CYP2C19*2 [ 26], but worldwide a number of other variants may have to be considered, in particular CYP2C19*3 [ 27, 28].
This was achieved by deriving a genomic relationship matrix (GRM) [ 34] for each class, and then estimating the proportion of total variance explained by the variants using the GRM in a restricted maximum likelihood (REML) analysis.
In an application, such as substance dependence, there are known pathways involved, so it may be of utility to determine whether there is a composite trait, the variance of which can be largely explained by the variants within the pathways.
We used a variance component analysis to determine how much variance can be explained by the variants in each class, over and above the same number of randomly chosen intergenic variants.
Assuming equal frequencies of males and females within a population, the proportion of phenotypic variance explained by the causal variant is given by λ = V G / (V G + V E ), where V E is the residual variance and.
It is similarly straightforward to estimate the posterior distribution for the proportion of variation explained by the rare variants, by dividing the variation of the prediction into two components, one corresponding to the rare variants, the other to the common variants.
p < 0.05 was considered to be significant, except for Cochrane's Q test for heterogeneity and Begg's and Egger's tests for publication bias, where a level of p < 0.10 was used.The variation in obesity-related continuous traits explained by the FTO variant was evaluated using the equation 2 f(1− f) a, where f is the frequency of the variant and a is its additive standardised effect [ 5].
We assumed an underlying genetic model where BC susceptibility is explained by the genetic variant of interest and a residual polygenic component that represents the multiplicative effects of several loci, each of which have small contributions to disease risk.
Here, we introduce methods that estimate the total trait variance explained by the typed variants at a single locus in the genome (local SNP heritability) from genome-wide association study (GWAS) summary data while accounting for linkage disequilibrium among variants.
