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As mentioned earlier, the explanation inference concerns the extent to which test performance can be explained by the targeted construct of pragmatic comprehension ability.
The lower recurrence risk in the latter studies may be explained by the targeted antepartum surveillance by health professionals in the future pregnancies for women with a previous stillbirth.
The relatively large number of identified contigs can be explained by the targeted 3′ nature of the 454 transcript sequence data that enables a high read depth representation of the 3′ ends of genes.
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Next, we focused our attention on those miRNAs that reduced Akt activation because their effect can be explained by the direct targeting of key players within the ErbB-Akt pathway.
This phenomenon can be explained by the direct targeting of miR-146a to the signal transducer and activator of transcription 1 (STaT1), a key transcription factor in IFN- γ response and in Th1 differentiation [ 21].
The median age for consumer participants was 60 years in comparison to 37 years for the Australian population [ 20] but this deviation could be explained by the specific targeting of medicine users whose higher median age was not unexpected as medication use and proportion of medicines used increases with age.
In each subsequent iteration, we choose the target that explains the largest part of the signal not already explained by the first target, while again minimizing the number of expected negative probes.
Conversely, other reports showed that inhibition of mitochondrial oxidative stress prevents metastasis [183, 184] and this apparent paradox might be explained by the different targets of antioxidants and their effect in different types of cancer cells [184 186].
In other words, we wanted to test if one mRNA could help explain the expression level of another mRNA that could not be fully explained by the miRNA targets alone.
The differences in patient outcome, compared with the findings in our study, may be explained by the different targets measured (mRNA vs protein) and/or the different composition of patient groups.
Thus, despite equi-potent inhibition of Bcr-Abl, IM and DST provoke distinct alterations of phosphorylation events, which can be explained by the broader target spectrum of the latter [ 37].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com