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This result might be explained by the stringent criteria used in our analysis, which was proposed in order to increase confidence and minimize the false positives.
False-negative identification can be explained by the stringent criteria of CNV calling that minimizes the false-positive but inevitably leads to a high false-negative rate.
It can be explained by the stringent criteria of CNV detection, i.e., containing three or more consecutive SNPs and presented in at least two individuals, which were applied in order to minimize the false-positive, and thus resulted in high false-negative rate inevitably.
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This might be explained by the more stringent conditions used for tissue homogenization.
The similarly higher coding rate in FMSC can also be explained by the more stringent coding requirement of specialty clinics.
Therefore, the smaller fraction of rigid binding sites compared to the previous study can be explained by the more stringent constraints used to build the dataset in the current study.
This effect was somewhat stronger in the HEBCS series, which may be explained by the more stringent cut-off used (20% positive tumor cells compared to 10% in the ABCS series).
Observed/expected ratios lower than 1 can be explained by the rather stringent criteria for inclusion into our study (for example, Cancer Registries include a variable proportion of DCO (death certificate only) cases).
This is partly explained by the other reviewer's more stringent inclusion criteria, which included a minimum of 50 subjects in each arm of the trial and an explicit statement that informed consent was obtained.
Second, this can be entirely explained by the fact that firms facing more stringent EP make a greater use of workers on temporary contracts.
The latter may be explained by the fact that WOSCOPS is a clinical trial where stringent exclusion criteria can result in lower mortality than observed in the general population.
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CEO of Professional Science Editing for Scientists @ prosciediting.com