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This might be explained by the effectively reconstituted (and in MS patients otherwise intact) immune system after the withdrawal of natalizumab.
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Therefore, and also because the PCs are oriented to best describe the spread in the data, projecting the data to this N-dimensional principal component space highlights the pattern explained by the captured variance and effectively reduces noise.
Intuitively, this rate acceleration can be explained by the weak purifying selection effectively lowering biases in the equilibrium nucleotide frequencies.
The result can be explained by the highly specific targeting efficiency, effectively sustained drug release, and efficient cytotoxicity enhancement effect of the MTX-targeted nanoscaled drug delivery systems, which lead to the enhanced cellular accumulation and retention of MTX. Figure 8 In vitro cell viability and intracellular delivery.
The observations in the rate constant plot can be effectively explained by the physical parameters in the EKE model and the sequence of rate events proposed in Tan, et al. [(2004b).
Dissection of the kinetic pathway of the ATP-induced structural changes in this active single ring can be explained by the fact that the mutation effectively blocks progression through the full allosteric pathway of the GroEL reaction cycle, thus trapping an early allosteric intermediate.
Unlike in subjects with type 2 diabetes and healthy volunteers (7, 8), we did not observe lower fasting glucose concentrations in the present patients, which might be explained by the inability of exenatide to effectively inhibit glucagon secretion with resultant unopposed hepatic glucose production (9, 10).
Mammalian germline cells are replete with small RNAs including endogenous siRNA (Watanabe et al., 2006, 2008; Tam et al., 2008; Song et al., 2011), and siRNAs in sperm and oocytes show a pronounced bias towards high-copy sequences that would be effectively explained by the selectivity of the RNAi system towards the products of high-copy loci (Watanabe et al., 2006; Song et al., 2011).
The synergistic effect can be explained by the complementarity of the two processes: ultrasound more effectively destroys the initial bisphenol A compound, whereas the photo-Fenton system is better able to eliminate the bisphenol A by-products.
This can be explained by the ability of the channel equalizer to effectively reduce the distortion of the phase per subchannel caused by small timing offsets.
The fitness responses under androdioecy show that compromised adaptive rates in the gradual trioecious populations, which until generation 35 remained effectively dioecious, cannot be explained by the loss of males and, therefore, by the existence of a cost of males.
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