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Lack of efficacy in other studies may also be explained by requirement of different concentrations of antagonists to inhibit bronchoconstriction.
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A fourth approach to explaining the Violation and Satisfaction Claims argues that the requirement violated, or satisfied, is, or is explained by, requirements on belief exclusively.
The reduced miR-24 level in retinoblastomas relative to normal retinas may be explained by the requirement of sustained expression of proliferation genes in tumor cells while maintaining sufficient amounts of miR-24 to repress the ARF tumor suppressor.
This might be explained by a requirement of Cat8p for full Hap4p activation or the necessity of Cat8p activation of its TCA cycle targets IDH1 and FUM1 [ 27].
That TSC patients do not have an increased risk of developing bladder cancer, or other sporadic cancers, may be explained by the requirement of cumulative genetic insults and the typically late onset of malignant disease.
The ATI-AS coupling in 5′ UTRs could be explained by the requirement of short 5′ UTRs for efficient initiation of translation (Wegrzyn et al. 2008), so that utilization of an upstream transcription start is compensated by AS.
However, the increased paraquat toxicity induced by G6PD overexpression and the protective effects of 6-AN can be explained by the requirement of reducing equivalents for paraquat to redox cycle.
This may be also explained by the requirement of different antibodies and by the different threshold levels of sensitivity in each method.
The incomplete penetrance is likely explained by the requirement of additional environmental or genetic factors for clinical manifestation of the disease.
The Violation and Satisfaction Claims would be explained by a requirement of reason to avoid or escape instrumental incoherence as such.
There are other challenges facing the view that the Violation and Satisfaction Claims are explained by a requirement of reason to be instrumentally coherent as such.
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