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No dose-limiting or other significant toxicities were observed at both dosages, which could not be explained by progression of disease.
This activation was increased under permissive conditions when compared to non-permissive conditions, which could be explained by progression through the cell cycle despite the presence of double strand DNA breaks.
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Although the mechanism of the resistance to mTOR inhibitor is unclear, disease progression after initial everolimus treatment may be explained by evolving progression mainly due to proliferation of the remnant resistant subclones.
Molecular, clinical and histopathological differences between RB1 −/− tumors are best explained by tumor progression, reflected by a gradual loss of differentiation and photoreceptor expression signature.
Our findings, therefore, support the theory that the increased bladder cancer risk among patients exposed to pioglitazone cannot be explained by disease progression.
As reported by others in young children, we found a high amputation rate in our study, explained by tumour progression in some cases (n = 5), but also by the complexity of surgical reconstruction in young patients, and by the lengthy study period.
This distributional difference in eGFR is probably explained by the characteristic progression pattern of diabetic renal damage.
The loss of correction in our PEEK-group does not reach the level of significance, but is notable and could be explained by a disease progression and loss of muscle strength of the older patient collective.
Moreover, it is interesting that the Flag-TDP-43 signal was selectively extended into Betz cells in the forelimb area of precentral gyrus contralateral to the injection side, which can be explained by a retrograde progression from α-motoneuron in the cervical cord.
MSCT coronary angiography in type 2 diabetes MSCT angiography has demonstrated a higher percentage of non-calcified and calcified plaques and a relatively lower percentage of mixed plaques in diabetes [ 53], which can be explained by the rapid progression of atherosclerosis.
The peaks of STM-LE were explained by the vibronic progressions related to the S1 transition because the peak positions in the PL and STM-LE spectra almost coincided with each other.
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