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Our results therefore further support the notion that pharmacoresistance in schizophrenia might be explained by enhanced P-gp expression lowering the brain accumulation of antipsychotic drugs.
Given these findings we hypothesized that the THC-induced reduction in brain risperidone and active metabolite concentrations might be explained by enhanced P-gp expression at the BBB.
Considering these findings, we hypothesized that the THC-induced reduction in brain risperidone levels might be explained by enhanced expression of the ABC transporter P-gp.
This behavior was explained by enhanced ionization of the background in a system of crossed electrical and magnetic fields.
The decrease in Voc can be explained by enhanced non-radiative recombination via Cu trap levels in the middle of the band gap.
The obtained result is explained by enhanced dye-loading (1.055 × 1017 molecule/cm2) and improved charge transfer resistance (Rct = 9.18 Ω) of the photoanode substrate.
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Such enhanced efficacy is explained by the enhanced permeability and retention effect, which represents the preferential uptake of liposomes by tumor cells due to the leakiness of the vessels traversing a tumor [ 34, 35].
This unexpected increase in thermal conductance can be explained by the enhanced phonon coupling at the G/M interface arising from the enhanced interface friction caused by the defects.
These features might be explained by the enhanced eastward electric field during daytime, and enhanced westward electric field during night time as we discuss in detail in "Discussion" section.
We propose that this discrepancy might be explained by an enhanced global C/O ratio.
The hysteresis can be better explained by the enhanced stability of active sites under reaction conditions.
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