It is explained by alter vasoconstrictive/vasodilatatory function, by triggering inflammatory processes (through NO and adhesion molecules such as ICAM-1, VCAM-1, and E-selectin) and by affecting haemostasis (through release of tissue factor, von Willebrand factor, thromboxane A2, and fibrinogen) [ 6].
Previous reports show that many observed phenotypic changes are in part explained by altered gene transcription.
The lack of differences between GC-I and GC-S patients in disease activity during pregnancy could also be explained by altering levels of glucocorticoid sensitivity, as was suggested by Majzoub and co-workers [ 47, 48].
The reading frame hypothesis proposed by Monaco et al 6 holds true in the majority of cases, although there are some exceptions, now explained by altered gene transcript processing.
Furthermore, the increase of rice growth and total N acquisition can be explained by altering expression of the OsPAD4 and OsNRT2.1 genes in aeration under LN and NO3-N supplies.
With regard to the effects of aging, there is controversy as to whether muscle from elderly subjects has an intrinsic defect in its capacity to transport glucose or whether muscle insulin resistance is a secondary phenomenon explained by altered body composition (10).
Because the seven cryptorchid boys, who all had exposed mothers, were omitted from the multivariate analysis, the observed differences cannot be explained by altered hormone concentrations and impaired gonadal development in cryptorchid boys (Main et al. 2006a; Suomi et al. 2006).
The change in white matter water content is therefore most likely explained by altered CSF/extracellular fluid flow and not by altered vascular permeability.
Even if our data do not confirm all presumptions of the ceiling theory, we found and altered information processing which presumably can be explained by an altered preactivation level.
There are 22 genes with stage-dependent expression alterations that cannot be explained by CNV, altered methylation, or dysregulated transcription, which suggests that other regulation programs responsible for expression alterations in the late stage are not included in the model.
The divergence is most likely explained by the altered microenvironment in the nasal cavity as the CFTR mutations leads to a modified mucus composition and structure as well as defective immune response.
