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This stable rate was probably explained by a stringent triage [24, 25].
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False-negative identification can be explained by the stringent criteria of CNV calling that minimizes the false-positive but inevitably leads to a high false-negative rate.
We suppose that it may be explained by more stringent selection of cachectic patients in our study with weigh loss criteria from 10to19%9% within 6 months (Table 1).
This result might be explained by the stringent criteria used in our analysis, which was proposed in order to increase confidence and minimize the false positives.
It can be explained by the stringent criteria of CNV detection, i.e., containing three or more consecutive SNPs and presented in at least two individuals, which were applied in order to minimize the false-positive, and thus resulted in high false-negative rate inevitably.
This might be explained by the more stringent conditions used for tissue homogenization.
When the findings are compared to the study in Uganda [ 11] in which proven sepsis was 37% among 293 neonates, the difference could be explained by stringent criteria used in the present study.
The similarly higher coding rate in FMSC can also be explained by the more stringent coding requirement of specialty clinics.
Observed/expected ratios lower than 1 can be explained by the rather stringent criteria for inclusion into our study (for example, Cancer Registries include a variable proportion of DCO (death certificate only) cases).
Therefore, the smaller fraction of rigid binding sites compared to the previous study can be explained by the more stringent constraints used to build the dataset in the current study.
This effect was somewhat stronger in the HEBCS series, which may be explained by the more stringent cut-off used (20% positive tumor cells compared to 10% in the ABCS series).
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