The simulation models presented here demonstrate that the pattern of LTP can be explained by a combination of declining incidence with age and a modest false negative rate in diagnostic assessment.
Dupuis et al. estimated that MTNR1B, GCK and GCKR were associated to T2D with modest effect sizes of 1.06 1.09 [48], so our result may be explained by a lack of power due to the small sample size.
Body shape differentiation in Lake Whitefish may therefore be explained by a complex polygenic architecture and the combined effects of relatively modest allelic frequency changes, as reflected by the low mean FST observed at the markers identified by the Random Forest analysis.
A more modest reduction of hospital days compatible with discharge was also observed in the control arm, which may be explained by a contamination effect, occurring in spite of the measures taken to ensure blinding.
Such a pattern can be simply explained by the modest mortality rates associated with HIV-2 [ 9, 10, 35], combined with the fact that as individuals get older, more time has passed for them to become infected.
This high prevalence of antipsychotic use cannot be explained by the modest success rate reported in the literature.
A confounding observation is the decreased use of opioids in the PACU during Epoch II which may be explained by the modest increase of intraoperative opioid administration.
This overrepresentation cannot be explained by the modest difference in nucleotide composition between these regions, consistent with the comparable distribution in the randomly simulated datasets (Table 1).
