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It is difficult to explain this altered swarming pattern in the strain degS S76D.
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Internal organs are potentially also subjected to the same counteracting forces, resulting in altered timing of growth spurts, which could explain the altered KD brain and heart percentage volume at E13.5 and E17.5.
Our findings explain the altered PAM specificities of the SpCas9 variants and establish a framework for further rational engineering of CRISPR-Cas9.
Based on these early studies, we speculated that DR6 6B) might in part explain the altered p53 regulation in HHV-6B-infected cells.
These alterations suggest that the cytoskeleton structures in general may be deregulated in the absence of mATX3, which may explain the altered morphologic features of mATX3-depleted cells.
Risk taking behaviour and cognitive deficits are more common among smokers, which may partly explain the altered risk for MSDs in adjusted models [ 1, 52].
A critical site for lesion-induced hyperphagia and obesity in rats is also the MePD (36), which may explain the altered pubertal timing by way of an earlier attainment of critical body mass (37).
Investigations into underlying mechanisms and the determination of gene expression levels that may explain these altered phenotypes have produced conflicting results [ 26- 28] which may reflect variations in the model systems used and the gender of the animals used [ 28].
Follow up studies demonstrated that changes in copy number of Stat5ab explained the altered immune and metabolic function.
Our NMR results explain this in terms of altered loop-6 dynamics in PGG/GGG.
Possible explanations that may otherwise explain this observation could be an altered immune system in patients treated with an extracorporeal renal replacement therapy and better preserved residual diuresis in peritoneal dialysis and pre-emptive transplant candidates.
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