Exact(1)
Taken together, these results point to several subversive mechanisms that may help explain the virulence of F. tularensis Schu S4 and reinforce its reputation as a stealth pathogen.
Similar(58)
This is what explains the virulence of Turkish Prime Minister Erdogan, who is himself a descendant of the Muslim Brotherhood line.
The immunosuppressive properties of gliotoxin may explain the decreased virulence of Aspergillus gliP mutants (Sugui et al. 2007); the presence of this cluster in W. dermatitidis suggests it has the potential to play a similar role in this organism.
This hypothesis helps explain the low virulence of the plasmid-free strains of both B. anthracis and B. cereus upon spore challenge [ 29] in spite of the highly toxic proteolytic capacity of these species.
Thus these differences in ARs of the two serotype 5 clones may explain the enhanced virulence of ST 289.
The specific combination of enhanced adhesion, survival fitness, Stx2 production and antibiotic resistance illustrates the high genome plasticity of this E. coli pathogen, and helps to explain the high virulence of the outbreak.
Bacterial virulence is normally dependent on several factors, and presence of Pla, although it is an exceptionally multifunctional and powerful virulence factor [ 8, 10- 16, 19, 19, 26- 28, 30, 31] does not alone explain the devastating virulence of Y. pestis.
The relatively large number of response genes unique to F. novicida or Schu S4 raised the possibility that some of these differences may help at least in part explain the high virulence of Schu S4.
In summary, we propose that high levels of biofilm production attenuate the cytokine response which may explain the increased virulence of B. pseudomallei UM6.
In addition, the phosphocholine (PCho) on cell surface was decreased, and the choline binding proteins (CBPs) were impaired, which may explain the attenuated virulence of the mutant.
The sustained high viral load in the lung, the tropism for the alveolar epithelium and the differential host responses to H5N1 viruses, individually or in combination, have been proposed as mechanism to explain the unusual virulence of this virus [7], [8].
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