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First, for switching mechanisms driven by noise, it is difficult to explain the robustness of cell type populations required for robust development.
We previously hypothesized that stiffer tissues might generate higher forces in order to explain the robustness of gastrulation to substantial natural variation in tissue stiffness [43].
Although not directly related to the lethality-essentiality rule, the scale-free model of biological networks is often used to explain the robustness of these networks.
As shown above, high-variance genes tend to be more stable expressed across platforms, which may explain the robustness of our PAM50 subtype classification results across platforms supporting its validity as a clinical assay.
Canalisation was introduced by Waddington to explain the robustness of phenotypes that he observed in experiments [ 251] and researchers have struggled to provide a precise basis for quantifying it [ 247, 252].
Reactions R34 (pyruvate dehydrogenase/citrate synthase), R36 (isocitrate dehydrogenase) and R41 (malate dehydrogenase) are steps in the TCA cycle regulated by ATP, which could explain the robustness of interactions between reaction pairs [R34, R36] and [R34, R41] [ 23, 25, 26].
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However, the word-level description considered is a "bag-of-words" representation which conveys only limited semantics, probably partially explaining the robustness of the description to transcription errors.
This also explains the robustness of our results to additional adjustment for fitness and stresses the clinical utility of this simple measure of physical activity intensity.
The independence of each neuron naturally explains the robustness of phase precession against intrahippocampal perturbations (Zugaro et al., 2005), an observation which is difficult to reconcile with models based on assembly interactions.
Our study, on the other hand, provides unequivocal evidence that PCNA stabilises p21 not only in tumour cells, but specifically within Cdk4 and Cdk2 complexes, which likely explains the robustness of Cdk inhibition and G1 arrest by p21.
From a linguistic point of view, such a set of 12 to 14 abstract and hierarchically organized features seems to be sufficient to explain the robustness and efficiency of speech recognition under various conditions like different speakers, contexts or different levels of environmental noise [ 8].
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