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Presence of a passive film at high R and self repair of the film and formation of an additional oxide layer at low R could explain the retardation.
38 These cumulative observations could well explain the retardation in DR progression found in previous studies 9 10 and the prevention of DR onset found in this study in participants with type 2 diabetes.
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This mechanism could therefore explain the growth retardation of infected-untreated mice.
Shilko et al. (2010c, 2011c) stated that increased levels of transforming growth factor (TGF-β1), found in the blood of alcohol misusing pregnant women, might explain the growth retardation in newborns.
However, crack closure cannot be used to explain the overload-induced retardation effects found in this work under plane-strain, where both crack arrest and delays were associated to an increase in ΔKeff.
The additional genomic imbalance detected by CMA may explain the clinical findings including growth retardation and dysmorphic features, which were inconsistent with 47,XYY karyotype in this patient.
Since our knowledge of the detailed genetic circuitry involved in the stringent response is limited, we have not attempted to develop a model to explain the origin of cell growth retardation due to protein synthesis.
Second, the growth retardation hypothesis cannot explain the observation that CR after maturity or in midlife; at a time when it will not affect growth or interfere with development, also extends life.
A contiguous gene syndrome involving fragile X mental retardation (FMR1 and FMR2) genes could possibly explain the unusual phenotypes seen in some severely affected patients [ 33].
To explain the accumulation of H2O2 in ssadh mutants and its severe growth retardation, we mentioned two possible hypotheses [26].
Parents of the older children were more likely to report mental retardation along with autism, but the finding did not explain the rising incidence.
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