Sentence examples for explain the responsiveness of from inspiring English sources

Several mechanisms to explain the responsiveness of cells to ultra-low doses and the similarity as inversion of drug effects, have again been suggested in the framework of hormesis and modern paradoxical pharmacology.

In order to explain the responsiveness of spleen cells of NP-mice to 4-1BB ligation, we analyzed whether Ag85B stimulation could induce the expression of this TNF-receptor on T cells.

This essay has focused on the concepts that have emerged to explain the responsiveness of the mitochondria to both global and local cues.

Dendritic segments located in these afferent sparse zones are likely to be activated mostly via intracortical connections that may explain the weak responsiveness of a subset of L5 neurons to single-whisker stimulation (de Kock et al. 2007).

The high induction of several JAZ genes in the fou2 mutant (Additional file 3 Table S1) indicates activation of the desensitization mechanism and may explain the reduced responsiveness of fou2 plants challenged with B. brassicae.

This reduced sensitivity to imipramine may explain the reduced responsiveness of patients with geriatric depression to the therapeutic effects of imipramine and other tricyclic antidepressants.

Finally, a decrease in fertilization gain because of ACS reactions in foliage of both species (hypothesis 3), stronger in beech, can partly explain the lower responsiveness of beech versus spruce to an elevated CO2 supply.

Intriguingly, the apoptosis remains unaffected upon 1,25-dihydroxyvitamin D3 treatment which may be explained by the responsiveness of LNCaP cell line to 1,25-dihydroxyvitamin D3 via increasing the expression of TRPV6 channel and therefore enhancing the resistance to apoptosis.

The lack of obvious molecular targets for the treatment of IBC partially explains the poor responsiveness of IBC tumors to therapy and highlights the need to identify new therapeutic options for the treatment of the disease.

Interestingly, Akt phosphorylation was not impacted by EZN4150 in UACC893 cells, despite robust p110α downregulation, perhaps explaining the decreased responsiveness of UACC893 cells to EZN4150 relative to BT474 or SKBR3 (Fig.  1e- f).

Further investigations should be carried out to better characterise the genetic profile and the pharmacological markers, which could explain the unfavourable responsiveness and prognosis of mucinous colorectal tumours.