In our samples, a reduced rate of p53 transcription to a level below that in normal bowel might explain the reduced p53 function in these cancers.
The absence of a significant correlation between cigarette pack years and fatigability of the muscle and no indication for changes in fibre type composition that could explain the reduced fatigue resistance in smokers suggest that smoking acutely hampers the oxygen and/or energy delivery.
The resulting smaller movement of the second upper premolars might therefore explain the reduced bone resorption in this area.
18 More specifically, there is age-related atrophy of muscle fibers, termed sarcopenia, which may also explain the reduced respiratory strength in the elderly.
A lower growth rate could not explain the reduced transcriptional regulation in this study because of the chemostat culture, suggesting that P. pastoris may be prone to reduce the transcription of some less important genes to supply enough energy and substrates for expression of the heterologous gene (here, RML).
Third, PPARβ deficiency led to increased PPARγ expression in vivo and in vitro, increased differentiation of MSCs into adipocytes, and increased bone marrow adiposity, thereby providing a new mechanism to explain the reduced bone formation in relation to glucose intolerance and lipid accumulation.
The possibility that this interaction with high doses of aspirin could explain the reduced antithrombotic benefits seen in the North American subgroup warrants careful consideration.
In the sensitivity analysis, if the prevalence of an unmeasured confounder that quadrupled the hazard for cardiovascular complications were 5% in the Chinese population, then its prevalence would have to be 40% in the European population to explain the reduced risk for cardiovascular complications observed in the study.
The novel finding that insulin stimulates PDE-5 expression can explain the reduced response to sildenafil therapy in diabetic patients with elevated insulin resistance and hyperinsulinemia.
Likewise, sustained NO release from percutaneously implanted microdialysis probes reduced tissue impedance to glucose transport, which may explain the reduced sensor lag time observed in the present study.
