To explain the reactivation during the 19th of April 2012 (Mejía and Meza 2012) we assume that there must be a large difference in the volumes of short term precipitation and that the triggering event during the 19th of April (or the day before) was not registered at the nearest stations.
Interestingly, a cluster of seven CpG dinucleotides proximal to the transcription start site (TSS) remained fully methylated after treatment, which may explain the weak reactivation of p21Cip1 in 501 mel cells (Figure 4A, 501 mel).
Concerning the southern East African rift, the graben geometries and the evolution of the subsidence during the Mio-Pliocene period may be explained by the reactivation of two main Pan-African inherited shear zones with an E W direction of extension.
The formations of the ridge systems were explained by the reactivation of basement faults that originated in the modification stage of a multiringed basin.
SYT-SSX1-mediated enhancement of IGF2 and H19 expression in this population must therefore have been achieved by alternative mechanisms since it cannot be explained by the reactivation of a silent allele.
We next sought to identify the epigenetic differences between the Xi of EpiSCs and MEFs that may explain the differences in reactivation of the Xi following nuclear transfer.
This would explain the cascade of herpesvirus reactivation in DIHS [ 12, 13].
Crucially, centromeric cohesin has an important role in augmenting SAC signaling during meiosis, and this phenomenon would explain why reactivation of the SAC is so weak [ 24].
Since H3K27me3 is maintained on the Xi of both MEF and EpiSC nuclei, this repressive mark does not explain the resistance of Xi(diff) to reactivation.
We evaluated two mechanisms in order to explain the development of this transtensional system: 1) reactivation of upper-crustal NNW-oriented Paleozoic shear zones, and 2) oblique stretching of a previous NNW-oriented lithospheric weakness zone.
