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Perhaps only Christopher Booker's enthralling The Seven Basic Plots could explain the potency of this appeal.
The inhibitor appears to mimic the substrate transition state, which may help explain the potency of this inhibitor and the catalytic mechanism of pyrimidine nucleotide phosphorylases (PYNPs).
These connections may help to explain the potency of activated RasV12 and YAP in transformation.
Based on structural analysis with GlcNAcstatin C [ 41] and GlcNAcstatin D in complex with CpOGA we can explain the potency of this inhibitor family.
Simultaneously inhibiting ATP production and Hsp90 chaperone activity may explain the potency of cruentaren A among the many different cancer cell lines and provides a novel approach to modulating the Hsp90 protein folding machinery.
This combination of roles may also explain the potency of mammalian YAP in control of tissue growth and its ability to induce cancer when overexpressed (Dong et al., 2007; Pan, 2010).
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This combination of lethal effects explains the potency of these peptides, which are active in nanomolar concentration.
While extensive biochemical investigations on the interaction of AHR with ligands have been carried out, studies comparing the abilities of specific computational algorithms in explaining the potency of known AHR ligands are lacking.
This explains the potency of this regimen in NSCLC, but clearly resistant patients exist, and indeed some tumors in this study were more sensitive to alternative regimens.
Indeed the dimensional characteristics of asbestos fibers are an important parameter influencing carcinogenicity in animals, but this parameter does not fully explain the potency.
Membrane and DNA damages, as shown by LDH and comet results, could explain the higher potency of MWCNTs-COOH to induce reduction of viable cells in BEAS-2B together with other cytotoxic processes such as apoptosis induction that could be the result of the particular contact of such CNTs with cell membrane that triggers a cascade of reactions leading to cell death.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com