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This phenotype has a TH2 low profile with predominant neutrophilic airway infiltration [36], which may at least in part explain the poor response to standard asthma therapy in this patient group.
During the discussion, various barriers were identified which could explain the poor response to cancer screening.
8 31 Heterogeneous groups of children with bronchiolitis and asthma may explain the poor response to oral corticosteroids in studies including infants and toddlers.
This may explain the poor response observed in response subgroups 3 and 4. Here, we also document that different responses to therapy can occur in different lesions within the same patient.
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Professor Salmon showed proliferation in CD8CD45RA+ memory cells, but only under stringent stimulation conditions; this may explain the poor responses reported for these cells.
Furthermore, the favorable allele at this locus is less frequent in African-Americans, partially explaining the poor response to treatment in the AA population [27], [30].
[4] [7] Neutralizing antibodies were not observed at 6 months in any of the 15 patients classified as poor responders, and so could not have explained the poor response to therapy.
The immaturity of the neonatal immune system and the impact of passively transferred maternal antibodies could explain the poor immune response in infants vaccinated at birth [ 43].
The chemostat cultures were metabolically active and in greater densities compared to the preliminary batch screening assays where hydrogen peroxide was added to lag-phase cultures, which may explain the poor transcriptional response for this condition.
Impaired drug penetration into hypoxic regions of tumours was thought to explain the poor prognosis, but recently an adaptive cellular response to hypoxia was demonstrated to reduce the cytotoxicity of many drugs.
It is worthy of mention that a high placebo response rate was observed, and this may partially explain the poor induction ability.
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