The amyloid hypothesis is still used to explain the pathogenesis of Alzheimer's disease.
Some authors have therefore argued that alloantibodies with a different specificity than MHC I might better explain the pathogenesis of BNP7,13,14.
These results may in part explain the pathogenesis of hypertension associated with certain disease states.
Among several conjectures, inflammatory injury orchestrated by podocytes is emerging to explain the pathogenesis of collapsing glomerulopathy.
Different theories have been proposed; initially, the "two hits" hypothesis was developed to explain the pathogenesis of the NAFLD spectrum (Day and James, 1998).
To explain the pathogenesis of these cases, the most accepted hypothesis will be the double hit theory: first hit, predisposition for disease as a consequence of primary mtDNA mutation, and second hit, the effects of genetic modifier.
Moreover, studying PAF-AH metabolic pathway may help to better explain the pathogenesis of APS and to improve management and interpretation of aPL-related issues, from the analytical results, to the final therapeutic decision.
Two theories have been proposed to explain the pathogenesis of basal ganglia involvement; the first concerns the accumulation of GAGs in neurons and astrocytes, leading to neuronal loss and demyelination; another theory maintains that the basal ganglia appearance could be related to an increase of fluid content in the periventricular spaces.
Several mathematical models have investigated the dynamics of the interaction in vivo among HTLV-I, the CD4+ target cells, and the CTLs immune response in order to explain the pathogenesis of HTLV-I-associated diseases [4 10] and used as a tool to study the role of immune response in the viral dynamics.
Driven by opposing findings, these studies led controversy whether these Th1/Th2 profiles could explain the pathogenesis of SSc.
We hypothesized that the gene expression patterns of OvHV-2 and the relative abundances of host cell transcripts in lymphnodes may be used to identify pathways that help to explain the pathogenesis of MCF.
