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Based on the analysis of the experimental data, a double-layer SEI film mechanism should be suggested and can well explain the mutation of the resistant and potential observed in the charge/discharge curves and EIS.
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Several models have been proposed that explain the mutation processes of microsatellites.
Finally, the same line of argument can also explain the mutation rate dependency of the A-catalyst evolution.
Different evolutionary histories along these lineages may be used to explain the variation of mutation rates.
Our results show that private mutations, ethnic specific mutations, and recurrent founder mutations could explain the mutational heterogeneity of XP-C group in Tunisia.
Therefore, similar to PAPOLG, the presence of four UGUAN sequences in the MC4R 3′UTR could explain why the mutation of the AUUAAA hexamer was tolerated in our earlier experiments.
The observed decrease in release activity of the hybrid release factor could also be explained by the mutation of the threonine in the PXT motif to a valine as found in mtRF1 [ 30, 31].
Our findings reveal a novel evolutionary mechanism for regulation of chromatin compaction and may explain the frequent mutations of the H2A N-terminus in cancer.
Inactivation of p53 allows cancer cells to proliferate in the presence of an activated ATM pathway (62), which explains the frequent mutation of p53 in advanced carcinomas.
Other studies, however, point to the existence of a trade-off between rapid replication and fidelity to explain the high mutation rates of RNA viruses [37].
Our observations suggest that although polymerase identity does affect the absolute frequency of slippage errors within TRs, it is not sufficient to explain the higher mutation frequency of small dinucleotide TRs in human genomes.
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