When he got in touch with the lady and asked her to explain the mice, she told him not to be silly.
In addition, the amino acid sequence dissimilarity between EV71 and CVA16 can partially explain the observation that mouse antibodies failed to cross-neutralize CVA16 (which may have similar structural organization like EV71).
This finding implies that the in vitro effects of 2DG on NB cells can be applied only in certain respects to explain the findings in the mouse NB xenografts, regardless of whether it is from DZ or from AS cells.
Several mechanisms might explain the difference: (i) mice may not be the most appropriate model to understand the function of the human PPYR1, as mice express a functional Y6 receptor (in humans only an non-functional pseudo gene exists) and this receptor could explain some of the results of the Ppyr1 knockout mice.
Differences between MSHORT1 and RSHORT1 should explain why the mouse miRNA cluster C2MC contains more miRNAs than its rat counterpart.
The absence of PWS region sno-lncRNAs in mouse also suggests one possible reason to explain the failure of current mouse deletion models to fully recapitulate pathological features of human PWS [ 27- 29].
Down-regulation of GLUT4 mRNA and protein in the endothelium and muscle of galectin-3 mice may explain the hyperglycemia experienced by these mice, and suggests a role for galectin-3 in the regulation of glucose uptake.
Could a less plastically sensitive brain of 8-10 week old mice vs. 6-8 week old mice explain the current null results?
To test whether murine norovirus, which wasn't present in the "clean" facility, could explain the difference in their mice, the researchers infected the ATG16L1 mice with a particular strain of murine norovirus, called MNV CR6.
We surmise that such fibers, which are significantly more prevalent in Mbnl1 ΔE3/ΔE3/mice3 Δexplain, explain the stronger myotonia in Mbnl1 ΔE3/ΔE3/Mbnl3 ΔE2 animals when compared with Mbnl1 ΔE3/ΔE3 mice.
