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This physiological remodeling may explain the exposure threshold of four ACEs since HR was significantly elevated among these children, suggesting alterations in neural regulation of the cardiovascular system.
The present study is part of a larger project whose main objective is to determine the environmental and anthropogenic factors that explain the exposure to Mn in the mining district of Molango, as well as to design and carry out a risk management plan.
Another explanation for cyanobacterial LPS-related diarrhoea is that the alteration in gut membrane permeability may be related to a cytokine cascade generated by circulating cyanobacterial LPS, but again, a hypothesis is needed to explain the exposure route for the LPS to overcome innate immune intestinal defences in order to gain access to the circulation.
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A combined index of PM 10), nitrogen dioxide, SO(2), and CO seemed to better explain the exposure-response relationship with total mortality than an individual air pollutant.
We surmise that differences in dietary exposure can explain the similar exposures observed among farmworker children, children living in the Seattle metropolitan area, and children sampled nationally.
Efavirenz and nevirapine decreased the relative bioavailability of artemether, which would explain the decreased exposure of the drug and metabolite.
The implementation of hygiene measures as well as the use of antibiotics and vaccines can explain the decreased exposure to different pathogens, particularly in Western countries.
To explain the observed exposure plateau in adults, it was suggested that the low solubility of bosentan may result in saturable absorption at higher doses [ 17].
13 Future studies should look at OAT3 polymorphisms in Indian patients because this could explain the increased exposure to and reduced clearance of pemetrexed observed in most subjects who develop hyponatremia.
Both of these enzyme systems have been reported to be induced during pregnancy (56, 57) and might explain the low exposures in pregnant women compared to literature values.
It is possible that the increased clearance associated with these differences may explain the lower exposures observed in this study, although these postulates are yet to be proven for anidulafungin.
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