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An impaired targeting or local accumulation of Munc18-1 at docking sites may therefore explain the docking defect in syntaxin-deleted chromaffin cells.
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These small reductions in Munc18-1 levels appear to be insufficient to explain the drastic docking defect.
However, the reductions in Munc18-1 level and localization observed in the present study were small and are unlikely to explain the complete docking defect.
Using computed MSEP of pMHC and TR interacting interfaces we are able to successfully explain the common docking geometry of almost all TR proteins on their respective pMHC binding interfaces.
Results from our MSEP analysis explain the common TR docking geometry on pMHC interface, seen in all TR/pMHC structures.
Syntaxin-deficient chromaffin cells showed a small reduction in total and plasma membrane staining for the docking factor Munc18-1, which appears insufficient to explain the drastic reduction in docking.
Due to Hyde's mental state, an intermediary was appointed by the court to sit in the dock to explain the proceedings to her.
The looming changes in the need for labor on the docks may explain the resistance the union has put up to the commission's campaign to diversify the work force in the ports.
Binding modes of representative structures were analyzed using the docking method to explain the observed disparity in HDAC1 inhibitory activities.
Docking computations explain the source of enhanced and inverted stereoselectivity.
The BBC's Jonathan Amos explains how the docking procedure will take place.
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