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This regulatory dichotomy appears to be important to explain the distinct effects when targeting CD22 that is closely linked to downstream functions of BCR activation.
To determine whether this differential regulation of IL-23 expression in the skin could explain the distinct effects seen in the absence of selected DC subtypes, we treated DKO* mice with a blocking monoclonal antibody directed against the IL-23R.
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Although the reasons for these differences have not been completely explained, the distinct effects of various BPs (e.g., pamidronate, zoledronate, and alendronate) and the use of different cell lines (e.g., human vs. rat and primary vs. cancer) could play a role [25].
Nonetheless, we found that the degree of openness of a country as well as the sectorial import content of exports could be also important elements in explaining the distinct effect of real exchange rate movements on the production growth of industrial sectors.
These differences may explain the distinct pharmacological effects of PDE4 inhibition in rodent and human hearts.
The focus seemed to be on the clothes, which might well explain the distinct lack of focus on the album.
Two possibilities could explain the distinct migration and distribution patterns of these DCs in the LNs.
Since the metabolic effects of p21 and p27 are most likely mediated by the inhibition of cdks, differences in cdk activity in these mice could explain the distinct phenotypes.
The absence of such confounds may explain the distinct heterozygous vocalization findings in the different studies.
The miRNA genotype-specific expression model might explain the distinct cold sensitivities between tea lines.
The distinct effects on DNA repair by the two schedules of sorafenib may partially explain the enhanced HCC viability with pre-irradiation sorafenib compared to the lower cell viability in irradiated HCC samples treated with sorafenib 24 post radiation.
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