Sentence examples for explain the discordance in from inspiring English sources

This may, in part, explain the discordance in the K-RAS mutation status between primary tumours and metachronous metastases.

We looked at the frequency of BCG vaccination among TST QTF patients to see whether this could explain the discordance in these patients.

For HER2 analysis, a recent meta-analysis including 26 primary publications has suggested that limitations of test reproducibility are less likely to explain the discordance in HER2 status found between primary tumours and metastatic sites [ 23].

Since angiogenesis is crucial for development and growth of all organs (including adipose), NOS activity may in part explain the discordance in body weight gain with the HFD in the different groups.

We had the impression that QTF TST patients had lower IFN-γ levels, suggesting that the low cut-off value for positivity might explain the discordance in these patients, but 10 of 28 patients who were QTF positive and TST negative had IFN-γ levels below 0.85 IU/ml.

To explain the discordance in phenotype, between mother and proband, the following possibilities were taken into consideration: i) presence, in the proband or the father's genome, of gross deletions/insertions in the pancreatitis causative genes; ii) presence of active modifier factors such as protective polymorphism p.G191R in the PRSS2 gene; iii) non paternity, and iv) environmental effects.

Immunohistochemistry staining has certain limitations, this cannot, however, explain the discordance observed between primary and metastases in the expression of HER-2 in the present study.

Although the hypothesis may explain the discordance due to different mutation loads in the first ovum cleavage, it still requires future investigation.

Consequently, the differences in age at initiation and the duration of HRT use were sufficient to explain the discordance between the WHI trial and the observational studies.

Finally, the genes identified have the potential to explain the discordance of the two twin pairs for schizophrenia.

In malaria, for example, the host immune response has been implicated as the cause of many symptoms of infection [ 8- 10] and may help to explain the discordance that is often observed between virulence and parasite load [ 11, 12].