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This suggests that obtaining a more complex and data-rich exposure metric, such as Hg dose, improves the strength of the exposure biomarker relationship but may not explain substantially more of the exposure variance than basic dietary data.
Given that the proportion of phenotype variance explained is a function of allele frequency and effect size [approximated as β × (2 pq ], limitations in sample size mean that many current sequencing studies are powered to detect only those single low-frequency variants that explain substantially more phenotypic variance than single common SNPs.
The idea is that, if the maximum-likelihood-SNP is in complete LD with the QTL, it will not only have a high Identity-By-Descent (IBD) probability with the QTL but also be alike-in-state (AIS) and thus will explain substantially more variance than a SNP that is only in partial LD with the QTL, such as the second highest log-likelihood SNP.
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The health variables models explained substantially more variance.
Results suggest that the IBD matrix explained substantially more variance than the IBS matrix, when they were fitted together in the model.
The any-stage ultrasound model 3 explained substantially more variability in endometriosis than the any-stage no ultrasound model 1 (Nagelkerke's R = 0.54 vs. 0.44 in phase I).
The preoperative EQ-5D index and EQ VAS explained substantially more than age; 3.9 times for the EQ-5D index and 1.9 times for the EQ VAS when comparing the impact of the variables on the model R-square value.
Compared to the SCMGENE subtypes, the PAM50 subtypes explained substantially more variation in gene expression for both PC1 and PC2 (Fig. 2a, b), with these components being especially prominent for the separation of the Luminal A (or ER+/HER2−/Low Proliferative) and Luminal B (or ER+/HER2−/High Proliferative) subtypes.
President Obama's proposed budget for fiscal-year 2012 does call for a mix of tax increases and tax cuts, but he hasn't made a serious effort to explain the need for substantially more revenue.
Also, given that there are 2 codons each for His and Gln, codon numbers do not explain why Gln is substantially more frequent than His.
A substitution between Leu and an amino acid like His or Gln in Column 3 is unlikely to be neutral, so the 6 2 ratio of codons for these amino acids does not explain why there is substantially more Leu than either of these.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com