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The feed-forward model simply uses the pattern of inputs to the cortex; while this model explains orientation preference, it cannot explain orientation selectivity.
As outlined earlier, although these models differ in the mechanisms invoked to explain orientation costs (e.g., spatial normalization or alignment, evidence accumulation, mental rotation, etc), collectively they claim that shape features are inherently bound to their spatial location in the image and, hence, to object orientation.
Further studies will explore to what extent these cues can explain orientation asymmetries in mouse lemurs.
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We thank the reviewers for their insight about importins that make extensive contacts with the NLS backbone, which may explain orientation-dependent interactions of the NLS.
We agree that we could have explained orientation of axes more thoroughly.
Additionally, a 2-D anisotropic modeling effort by (Beike2001) yielded a narrow, anisotropic conductor comparable to the Atacama Fault which may explain the orientation of the induction arrows, but this model could not explain phases above 90°.
A simple theoretical approach based on Rouse modes was developed to explain the orientation dependence of the hard segments on the number average molecular weight of the soft segments.
The hypothetical landscape can explain the orientation of all the denticle rows.
The LH and RH sites in the attC are possibly distinguished by the integrase, which might explain the orientation of integration of the gene cassettes.
No mechanistic model is available for IS110 that could explain its orientation, but, as mentioned before, specific targeting could also be involved.
The strongly asymmetric content of β associated with synthesis of the leading versus lagging strands in B. subtilis could explain the orientation bias found for IS families in Firmicutes (fig. 4 C).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com