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When Carson says that scientists rely on "probability theory" to explain how multiple Big Bangs, taking place over "billions of years," have resulted in our "perfectly ordered" universe, he's profoundly misstating the theory of the Big Bang.
Synaptic tagging does not explain how multiple weak stimuli can result in a collective stimulus sufficient to induce LTP (this is explained by the postsynaptic summation of EPSPs described previously).
Synovial fibroblasts also can migrate in the bloodstream to invade distant cartilage in mouse models [ 22], which may explain how multiple joints are involved in rheumatoid arthritis.
If correct, the increased accuracy in downstream gene expression stemming from Qrr dosage compensation could explain how multiple copies of the qrr genes have been selected and maintained throughout the Vibrios.
Historically attempts to explain how multiple phenotypically distinct cell types arise within the crypt have assumed the creation of lineage-restricted progenitors that can be distinguished by different transcription factor profiles [ 1,2].
The tethering of PDE isoforms to specific sub-cellular locales via isoform-specific N-terminal and conserved regulatory domains allows for the paradigm of compartmentalised cAMP dynamics to explain how multiple independent cAMP signalling events can occur simultaneously (Houslay, 2010).
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In his extraordinary book, "When Affirmative Action Was White," my colleague Ira Katznelson documents and explains how multiple policies of the mid-twentieth century, from Social Security and the G.I. Bill to new labor laws and home-mortgage assistance, promoted the modern American middle class.
The AKAP-PKA-R interaction functions to sequester PKA in the vicinity of its phosphorylation substrates [ 2, 8, 9] and this selective concentration of PKA activity in part, explains how multiple diverse extracellular stimuli can result in highly specific and discrete PKA-mediated phosphorylation events [ 10, 11].
But the theory does not offer any mechanism for state collapses, and it does not explain how the multiple collapses are related to each other and how our experience is accounted for in light of this multiplicity.
Crosstalk among pathways by floral integrators such as FLC, FT, SOC1, LFY, AP1 might explain how the multiple signals affecting flowering are coordinated.
Thus, crosstalk between pathways might explain how the multiple signals affecting flowering are coordinated, and differences in how pathways are integrated might underlie the diversity of plant flowering [ 3, 6, 17].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com