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It is known to have a longer plasma half-life than other 5-HT3 receptor antagonists, but this alone is insufficient to explain efficacy in the delayed phase.
Evidence is accumulating that metabolites of dietary polyphenols may mediate, or substantially contribute to, the pharmacological efficacy of the parent molecule, and thus explain efficacy despite the apparent low bioavailability, as is observed with 1,3,4′-trihydroxy trans-stilbene (resveratrol), which is found in grapes (Gescher and Steward, 2003).
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When Vance Gellert studied pharmacology in the early '70s, he found that a scientific method of systematic observation, precise measurement and disciplined testing could explain the efficacy of most treatments.
In either case, however, the account given is intended to explain the efficacy of the science of astrology.
Some of these mechanisms can explain the efficacy of NSAIDs in chronic pain conditions such as rheumatoid arthritis.
Additionally, 5-HT1B/1D receptors are present in the brain stem [39], which could explain the efficacy of triptans and alkaloids in migraine.
And these studies will, hopefully, be guiding factors in futuristic endeavor to scientifically explain the efficacy and the overall mechanism of action of traditional Chinese medicine.
There is controversy regarding the best technique for applying Kinesio Taping (KT), and the theory supporting that skin convolutions may explain its efficacy has recently been challenged.
A numerical study has been carried out to explain the efficacy of the model along with the trade-off among the multiple objectives.
Amygdala kindling has been proposed by Post and Weiss ([1989]) as a model of epilepsy to explain the efficacy of the anticonvulsant carbamazepine in treatment of mania in patients with bipolar disorder.
Although one could speculate that DBS is ineffective in chronic CH, several bias, mainly related to the study design, might explain that efficacy of DBS has not been demonstrated in the randomized phase.
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CEO of Professional Science Editing for Scientists @ prosciediting.com