Exact(6)
The purpose of this study was to test nongenetic factors that might explain discordance for dementia in monozygotic twin pairs.
The choice of one model over the other can often explain discordance in the statistical significance of observed treatment effects.
Differences in immunological responses can partly explain discordance and might have important clinical and programmatic implications, as recent infection is more likely to progress to active disease and preventive treatment therefore indicated.
Furthermore, recent studies have questioned the exclusive ability of XCI status to explain discordance between individuals with identical MECP2 mutations but different severity, suggesting the influence of genetic modifiers [ 13, 14].
The quality of the DNA does not explain discordance with the literature, as methylation was also observed in both groups and no difference in the extent of methylation was seen between FFPE or flash-frozen tissues.
Substantial reductions in missed presentations in those acquiring HIV in high-risk regions, suggested increased awareness of transmission risks, while patient factors, including access to alternative health insurance, may explain discordance with findings of barriers to diagnosis for some migrant populations [ 22].
Similar(54)
Many factors could explain discordances between OLPs recognized in our study and the BDE list.
Similar phenomena in humans may also help to explain discordances in age at onset of up to 8 years in twins carrying the inherited prion mutation P102L [16], [16].
This can partly explain discordances observed in our study.
Hypotheses explaining discordance in phylogenetic congruence implicate independent speciation, extinction, lineage duplication of either host or associate as well as horizontal transfer between host species.
However the hypothesis was proposed before the analysis was performed (ie. it was not data-derived) and it would explain the discordance between the results of the randomised trials and the MTHFR studies.
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