Sentence examples for explain a role from inspiring English sources

The potential mechanisms that could explain a role for periodontal disease in atherosclerosis are general inflammatory mechanisms and specific bacterial interactions.

Our results support that OCT4 inhibits p53 but stimulates p63 (as described in this study), which provides an additional regulation of p63, which helps to explain a role of p63 in stimulating tumor development.

The model may explain a role of the IBR in enhancing E2 binding that has been suggested previously for Parkin (Zhang et al, 2000; Tsai et al, 2003) and other RBR E3 ligases (Moynihan et al, 1999).

The over-expression of for example AKR1C4, SULT2A1 and SULT2B1 in high androstenone animals does not explain a role for these genes as inactivation enzymes and the role of these genes needs to be further studied in relation to androstenone levels.

Therefore a possible scheme to explain a role for MDM2 SNP309 G/G in BRCA tumors could be that overexpression of MDM2 in BRCA1/2 tumors results in down-regulation of p53 and allows the development of BRCA1/2 tumors similar to the effect induced by a mutation in p53.

One of the most accredited hypotheses explaining a role of autophagy in supporting the DDR is that by degrading damaged mitochondria (mitophagy) and toxic aggregates, autophagy eliminates putative sources of ROS, reduces their levels and, if only indirectly, decreases DNA damage accumulation.

Excess mucus is induced by multiple airway offenders through nonspecific pathways and would explain a cofactor role of Pneumocystis in respiratory disease.

This may explain a dual role of MIWI in protecting or degrading mRNAs, depending on its state of piRNA loading as well as the association of CAF1.

Although at this stage whether PSA-NCAM molecule itself plays a causal role or is a downstream consequence of changes in tumorigenesis is not known, some hypotheses may be formulated to explain a negative role of PSA-NCAM in survival.

If Kumar and coworkers suggested mechanism of transient lowering of viscosity is correct, then this would explain a dominant role of reducing afterload on both right and left ventricles.

Despite the fact that the rs1800497 SNP is localized to the ANKK1 gene, it seems to be in linkage disequilibrium with several DRD2 genetic variants, which could potentially explain a dopaminergic role in the etiopathogenesis of schizophrenia [ 20].