Additionally, the lack of resources (time and skills or expertise) limited their participation.
However, DSA is invasive, costly, time-consuming, and demands expertise, limiting its use to a certain pool of medical professionals [ 23].
These techniques are not readily scalable for high-throughput investigations and require skilled technical expertise, limiting their potential for biological studies.
Aubrey K. McClendon, chief executive of Chesapeake Energy, a major domestic shale oil and gas producer, said that production would be constrained by the small number of companies with shale expertise and limits on access imposed by some countries.
Simon's inquiry into expertise — its limits, its specificity, its structured impulse to provide adequate solutions rather than ideal ones – led to his Nobel-winning theory of "bounded rationality".
The questions, however, are whether expertise has limits and whether excessive dependence on expertise to solve problems and manage human affairs might be at times insufficient and even harmful.
The traditional approach of forming a lipid bilayer across a microscale aperture is extremely flimsy, requiring high level of expertise, which limits throughput.
The notion of professional expertise, its limits, and potential for liability were specific challenges identified in the process of first determining actual clinical risk, and second explaining this risk to patient-participants.
This also means that the openness towards other forms of expertise is limited, as they only have limited attention for it and only limited interest.
