The present paper evaluates five methods for building Conditional Probability Tables (CPTs) of Bayesian Belief Networks (BBNs) from partial expert information: functional interpolation, the Elicitation BBN, the Cain calculator, Fenton et al. and Røed et al. methods.
"Conversion disorder really refers to people who've developed symptoms like paralysis, or movement disorder, so some kind of neurological symptom," Dr. Jon Stone, a professor of neurology and expert on functional disorders, told VICE.
Each UniProtKB/Swiss-Prot entry contains not only manually annotated protein sequence(s) encoded by one gene, but also expert curated functional annotations, mostly gathered from the scientific literature.
Whereas experts use functional attributes for understanding, non-experts who do not have the appropriate knowledge about attributes use superficial features for categorization and rely on similarity (Gregan-Paxton and John 1997).
According to questionnaires answered by experts, the functional assessment system is composed of six oriented components, 13 main indicators, and 29 sub-indicators.
An expert-driven functional selection approach was also performed to select individual proteins for comparison to our automated approach.
We have developed an expert-curated functional genomics standard and a methodological framework that address the problems we have identified.
In the expert-driven functional selection, the biomarker candidates were selected as the several most differentially altered proteins belonging to the functional clusters providing the best integrated CAs.
At the level of individual proteins, four out of the six candidates selected by the expert-driven functional selection were also identified in human plasma samples.
In contrast, the expert-driven functional selection may be somewhat subjective; however, it can be an efficient way to extract a handful of biomarker candidates with the incorporation of proper knowledge.
