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However, transfection experiments (Figs. 6a and 6b) suggest promoter activity closer to the repeat tract and experiments to define the 5′ end of the CAG transcript(s) still need to be performed.
To gain insights into the differential responses of CNS and PNS neurons to reduced neurofibromin function, we designed a series of experiments to define the molecular mechanism(s) underlying the unique CNS neuronal sensitivity to Nf1 heterozygosity.
FOXP3-ΔN was thus used in subsequent experiments to define the DNA-binding specificity of FOXP3.
Mutagenesis experiments to define the role of different potential ets and other transcription factor binding sites in the regulation of IGF-1 expression are ongoing.
Past experiments to define the role of C6-aldehydes in plant defense responses were biased towards the exogenous application of the synthetic metabolites or the use of genetic manipulation of HPL expression levels in plant genotypes with intact ability to produce the competing AOS-derived metabolites.
Having shown that pre-treatment with AtGV3101 suppressed pathogen growth, symptom development, defence-associated cell death (HR) and SA production, we performed a series of experiments to define the conditions in which AtGV3101 was able to suppress P. syringae-elicited symptoms and SA production.
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Next we performed a time course experiment to define the time frame during reprogramming for which MBD3 is required.
We performed a time-course microarray experiment to define the transcriptional response to carboplatin in vitro, and to correlate this with clinical outcome in epithelial ovarian cancer (EOC).
NCIS uses windows of low and randomly distributed sequence counts within each experiment to define the background and to separate it from the signal.
We therefore performed experiments to define how IL-18 might promote the IFN-γ production and the cytotoxicity of NK cells in visceral leishmaniasis.
Multiple GBM cell lines are known to contain TMZ resistant cells and several acquired TMZ resistant GBM cell lines have been developed for use in experiments designed to define the mechanism of TMZ resistance and the testing of potential therapeutics.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com