In another experiment of acute toxicity, different solvent extracts, namely, n-hexane, methylene chloride, ethyl acetate, and methanol extracts of F. vulgare upto 5.5 g/kg concentration, did not revealed any kind of toxicity in mice, LD50 being: 6.75, 11.0, 6.92, and 15 g/kg for n-hexane, methylene chloride, ethyl acetate, and methanol extracts, respectively [ 68].
Hence loss of Aβ by diffusion may complicate interpretation of the effects of Aβ in experiments on acute slices from APP overexpressing mice.
They can be tightly controlled, can usually be undertaken quicker than ex vivo and in vivo experiments models of acute I/R injury, and can assess the direct effect of the novel cardioprotective therapy on the cardiomyocyte itself.
One cow was excluded from the experiment because of acute spontaneous coliform mastitis after the first challenge.
Littermate Opn4Cre/+ R26iDTR/+ and WT mice were used in all subsequent experiments for acute ablation of mRGCs.
In another part of experiments, acute effect of various doses of the Rosmarinus officinalis extract on blood glucose and serum insulin levels was studied in alloxan-induced diabetic rabbits.
The present experiments investigated the effects of acute methylphenidate and atomoxetine in male long Evans rats in the 5-choice serial reaction time (5CSRT) test that is hypothesized to serve as a model of vigilance and impulsivity behaviors associated with ADHD.
The first series of experiments tested the effects of acute blockade of DA receptors by bath application of either the D1 antagonist SCH23390 (5 µM) alone (n = 9), or a combination of SCH23390 and the D2 receptor antagonist sulpiride (5 µM; n = 5).
Most of the experiments on the effects of acute sleep deprivation were conducted in healthy, lean volunteers.
We must be even more careful when applying the results of acute experiments in animals to the pathophysiologic changes observed in prolonged exposure to environmental pollution in humans.
