In our experiments, loss of RA does mildly affect liver formation.
In these experiments, loss of either immunocompetence or immunogenicity could lead to tumor outgrowth.
In our experiments, loss of neither SFRP1 nor FRZB in Sfrp1 −/− or Frzb −/− mice alters fibrotic outcomes compared to WT mice.
In these experiments, loss of fluorescence from a fluorescein-conjugated lipid in the bilayer reported the pH drop, and dequenching of a hydrophobic fluorophore (DiD) introduced into the particle membrane reported the time of membrane merger and dye diffusion into the bilayer.
However, as seen in the common garden experiment, loss of only partly decomposed material from the litterbags through the mesh can become a problem as decomposition progresses.
The biggest diameters during the fixation period was noted in the group with best nerve fibres survival (Group 2 1 mm/day in 60 steps) but, even in this group at the end of experiment, loss of fat tissue in the epineurium of the lengthened nerve was dramatic and accompanied with 6% loss of myelinated nerve fibres.
In this experiment, loss-of-function mutations with dominant-negative actions, which would exert greater effects with increasing protein concentrations, will show a positive correlation between mutant protein concentration and EC50.
These data are also consistent with cell ablation experiments where loss of some chemosensory neurons affects C. elegans lifespan, while loss of other chemosensory neurons has no effect (Alcedo and Kenyon, 2004).
Other smaller foundations in the Pittsburgh area, like the Hillman Foundation, have said they, too, are withholding support for the school system, and since private money often underwrites innovations and experiments, the loss is more significant than its dollar value.
In both experiments, complete loss of activity demonstrates the importance of sequence context in determining whether substitutions are functionally acceptable.
