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These findings also provide evidence for the importance of animal experiments in studying the multiple action and crosstalk among different biochemical pathways provoked by the administration of xenobiotics.
The controversy surrounding 'gain-of-function' experiments on high-consequence avian influenza viruses has highlighted the role of ferret transmission experiments in studying the transmission potential of novel influenza strains.
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The Lego Cars experiment was more explorative with only a vague protocol, whilst the synthetic chemistry experiments in Study 1 and 2 were clearly defined.
Experiments in Study 1 were designed to be carried out in two-week intervals.
SOL carried out the majority of the experiments in this study, designed study, and wrote manuscript.
The experiment in study 2 was conducted to verify the effectiveness of AD and CV.
Thus, we designed an experiment in Study 2 to increase internal validity.
GMC participated in animal experiments, assisted in study design, performed protein and gene expression assays and immunohistochemistry. YL participated in animal experiments and assisted in mouse study design.
A.T. and C.S. performed all the experiments in the study.
C.Z. performed all the experiments in this study.
All experiments in this study were carried out in accordance with our university's ethical guidelines.
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