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As interpretation and use of available experimental data depend on the model structure, techniques for design of experiments for selection of the best model are of fundamental importance.
We review here our experiments for selection of phage display antibody libraries against microbes and tumor cells, as well as the recent literature on the selection of phage display antibody libraries to multiantigen targets.
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Results of experiment for selection of optimal amount of temperature lowering additives and their influence to physical mechanical characteristics of asphalt mix are presented too.
We often describe experiments by relating their motives (ie, adaptation and innovation), but complex systems see only experiments available for selection.
In classical statistics, ensemble non-centrality constitutes the reference technique to design experiments for model selection (Atkinson and Fedorov, 1975; Ponce De Leon and Atkinson, 1991; Skanda and Lebiedz, 2012).
As a consequence of previous results from submodular optimization (Feige, 1998; Krause and Guestrin, 2005; Nemhauser et al., 1978), we could prove that the greedy method exhibits the best constant approximation factor (unless P = NP) to design experiments for the selection among alternative dynamical systems.
Experiments for the selection of genetically resistant animals can be traced back as early as the 1930's [ 4, 5] and the first step was the demonstration that distinct disease resistances or susceptibilities exist between different lines or breeds of chicken.
Studies that were randomised control trials (RCTs), quasi-experimental and natural experiments were eligible for selection.
Briefly, cells were grown at 30° in YEPD (or SD for experiments requiring selection for a plasmid), with shaking, to OD600 of 0.6.
In a previous experiment for dose selection, we conducted an acute toxicity study with three dose levels of 1250, 2500, and 5000 mg/kg.
These studies were all selection experiments for different environmental conditions such as selection for positive or negative geotaxis in houseflies, selection for differential temperature and humidity in Drosophila, and selection for spatiotemporal habitats, phototactic and geotactic behaviour in Drosophila [29]-[31] [29]-[31]
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