In five different experiments, dose-dependent chemotaxis of GC B cells was observed (Fig. 2C).
NJL carried out the cloning studies, subcellular fractionation, participated in study design, neurosphere experiments, dose-response testing and Western analysis.
In animal experiments, dose-dependent increase in natural killer (NK) cells has been observed, together with activation of lymphocytes T4 and T8 and polarisation to the Th1 profile.
In these experiments, dose-dependent acidification by up to around 0.8 pH units was seen within 1 h after the addition of cis-UCA at pH 6.5 but only by less than 0.2 units at pH 7.4, confirming the pH-lowering effect of cis-UCA in bladder cancer cells.
However, in similar experiments doses of other antagonists within this range have proven to be effective [ 31].
In preliminary experiments, doses of LPS used in young adults (5 mg/kg) induced 100% mortality in senescent rats within the first 12 hours of endotoxemia.
Unless otherwise stated, both enzymes were in all experiments dosed to a concentration of 500 nkat/mL of liquid based on the activity of the preparation.
In cell culture experiments, doses of 50 100 μM MSC have been shown to inhibit mouse mammary epithelial tumor cell growth effectively [ 4, 8].
After the single-dose experiments, multi-dose (25 mg dose) pharmacokinetic study was assessed with im administration of levosulpiride every 12 hours on the five consecutive days.
For this experiment, doses of glibenclamide were administered every 24 h for 7 days.
