In this sense, B-Value threshold in methylation experiments is an issue that needs to be seriously addressed; hence setting a valid threshold for methylation change between two conditions may be helpful in obtaining more accurate list of significantly methylated or unmethylated genes.
For the farmers and for the Zambian government, the migration amounts to a new experiment on an issue central to the whole region: how do whites fit in?
If CK's are the subject of such an experiment, an important issue to determine is whether the CK originates from the investigated tissue or whether its presence is a consequence of contamination from the laboratory environment.
The deformation of microstructures on the surface of microchannel walls during fluidic experiments may be an issue due to a strong shear force applied.
Dealing with the heat losses associated with steam-assisted gravity drainage (SAGD) experiments has been an issue for which different heat loss prevention techniques have been developed and utilized in the literature.
Whether animals could be used for multiple experiments was also an issue largely resolved in the favor of scientists".The most important [issue is] the removal of restrictions on the use of nonhuman primates and the ability to reuse animals," said Simon Festing, chief executive of Understanding Animal Research, a British advocacy group promoting the need for humane animal research.
On the other hand, Ms Leibovitz's experiment does raise an issue much more tantalising than the question of whether Yoko Ono looks good in a top-hat and fishnets, and this is the difficulty that the average man experiences these days in the presence of female beauty.
As shown in MNase-seq and ATAC-seq experiments, this sensitivity represents an issue only when mapping larger fragments (>100 bp) because the data is heavily biased by the overall nucleosome configuration at the region [ 55, 103].
The benefit of using this approach is that differences in scale/resolution between different experiments are no longer an issue because the Pearson correlation between two variables is invariant (up to a sign) to changes in location and scale of each variable.
Such confounders are not an issue in experiments carried out in vitro, and results from experiments studying the effects of spiritual healing on bacteria (Nash, 1982), yeasts (Haraldsson and Thorsteinsson, 1973), microorganisms (Pleass and Dey, 2005), or human cells in the laboratory (Braud, 1990) have been published.
