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Despite repeated siRNA experiments, a reduction in CXCR7 mRNA or protein beyond ~30% was unattainable in siRNA-transfected LNCaP cells.
In previous experiments, a reduction in retention force by drilling out bone grown into longitudinal grooves on each side of the novel stem was demonstrated [ 6].
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Although it was not measured in this experiment, a reduction in hepatic glucose concentrations has been observed in aged mice [17].
Experiments showed a reduction in pesticide usage of about 34.5% by means of variable-rate technology (41.3, 25.6 and 36.5, respectively for the top, middle, and bottom sections of tree canopy).
Locking the actin binding domain in a closed conformation using engineered cysteine residues in each calponin homology domain reduced the affinity for F-actin without affecting the stoichiometry furthermore differential scanning calorimetry experiments revealed a reduction in melting temperature on binding to actin.
These experiments showed a reduction in the values of Young's modulus and yield stress with increasing temperature.
Similarly, RNAi experiments show a reduction in dendritic targeting of the β-catenin-cadherin complex, suggesting that LAR-RPTPs function in maintaining excitatory synapses and dendritic spines (Dunah et al., 2005).
In agreement with this possibility, preliminary experiments show a reduction in protein levels of the muscle isoform of GP in hypoxic c2c12 cells (data not shown).
Aimed at modeling the crowded environment of the cell, recent experiments showed a reduction in fibrillation halftimes for amyloid-forming peptides in the presence of cosolutes that are preferentially excluded from proteins and peptides.
The efficacy of roscovitine as a CDK inhibitor was confirmed in separate experiments demonstrating a reduction in immunoprecipitable CDK5 activity (results not shown).
IL-1 β led to decreased SERCA2b mRNA and protein expression, whereas time-course experiments revealed a reduction in protein half-life with no change in mRNA stability.
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