The experimentation points out the destabilizing effect of the internal friction in the over-critical rotor running.
Together this line of experimentation points to a crucial role for ATP binding (not hydrolysis) in the disassembly of oligomers and showcases the sensitivity of BiP to details of the nucleotide.
Markram's response to this is that he has never said his brain simulation is a replacement for animal experimentation; the point is to use the simulation to suggest lines of research that are likely to be most profitable.
Some Bush paintings that leaked last year, including ones in the shower and the bathtub, were startling not merely for their unexpected setting (and ex-Presidential skin) but because they, with their primitive experimentation with point of view, suggested a kind of soul-searching.
And yet for all of that, there's been relatively little smart, written-out and well-scored experimentation," a high point being John Coltrane's legendary cover of "My Favorite Things".
If I want to understand a particular food better I try making it from scratch and so I've done plenty of sausage experimentation (I should point out here that my six years of expensive therapy were all Jungian so I can obsess about sausage without the slightest fear of subliminal phallic significance).
And, as Sasha Issenberg shows in his enlightening new book, "The Victory Lab," the ground game has been revolutionized in recent years by technological innovation and clever experimentation, to the point where it may well have a bigger impact on Election Day than all those millions in ads.
My colleague Richard Lenski, whose own long-term investigation of evolving populations of E. coli set a new standard for direct evolutionary experimentation, likes to point out that such observations of evolution in action are not really new but have been taking place since Darwin's own time.
Books like My Life In Orange, or Frances Fitzgerald's magisterial dismantling of Rajneeshpuram in Cities on a Hill, have underlined the point that experimentation with the norms of society is like putting machine-guns in a nursery.
They use it as a starting point for experimentation with a wide range of traditional instruments, including accordion, longneck lutes, Uzbek dotar, flutes, dumbek, tabla, frame drums and tapan.
