We designed a novel laboratory sediment flux chamber in which we maintained the headspace O2 partial pressure at preselected values, allowing us to experimentally regulate "in-situ" O2 to evaluate its role in net N2O production by an intertidal estuarine sediment (Tyne, UK).
Experimentally, p53 regulates at least 34 different miRNAs in oncogenesis (for example, mir-34; reviewed in [ 12]).
To assess this, we simulated an additional system (see Table 2) that has been shown experimentally to regulate IP3R1 sensitivity: the phosphorylation state of IP3R1.
Genes encoding proteins secreted by T3SS and T2SS have been experimentally proved to be regulated by HrpX [ 33, 62, 63].
Previously, four Salmonella operons have been experimentally shown to be regulated by σ: prpBCDE[ 4], glnHPQ[ 27], argT[ 2], and glnALG[ 29].
Interestingly, Nfkbiz was not annotated by the database, but was experimentally shown to be regulated by RNA stabilization related to the 3'UTR [ 37].
Thus, gene selection by unsupervised meta-analysis was able to pinpoint biologically important genes of which many are experimentally validated to be regulated by pathogen attack.
In their meta-analysis, Marguerat et al. used a small set of experimentally validated cell cycle regulated genes to align the cell cycle stages of all ten experiments.
Applying LIGAP to time-course data from multiple Th cell lineages, we identified and experimentally validated several differentially regulated Th cell subset specific genes as well as reciprocally regulated genes.
Recently several E. coli operons, not related with catabolism, were experimentally verified as being regulated by Crp, included also the yhfK [ 21], suggesting that the lack of yhfK expression could be due to lack of Crp.
