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We investigated in silico the expression of 369 genes experimentally recognized as involved in establishing and maintaining epithelial cell identity and mammary gland remodeling, in HELUs or ADHs with respect to the corresponding patient-matched normal tissue.
A motif of six amino acids in length, which distinguishes the PCV2 subtypes, is located at positions 86 to 91. 11 However, the motif region has not been experimentally recognized as immunogenic thus far, except for the last three residues, 55 but could form as-yet-unidentified conformational epitopes.
Here we used publicly accessible microarray datasets to compare, in a series of HELUs from noncancerous adult breasts and corresponding patient-matched, normal TDLUs, the expression pattern of genes experimentally recognized to be involved in regulating cell identity and mammary gland remodeling.
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Studies of aptamers — RNAs selected experimentally to recognize small molecules — demonstrate that RNA can discriminate between closely related structures at least as well as antibodies can10.
Our results suggest that the F− and AcO− anions are recognized experimentally due to a combination of strong interaction and large infrared (IR) shifts upon complexation, verifying the remarkable IR-reporting ability of the Cr(CO 3 moiety and its potential applications in anion recognition.
The sensitivity of the optimized PWM is calculated as the number of experimentally confirmed sites recognized by the new matrix.
A variety of receptor motifs, ranging from 4 to 12 nt, have been recognized experimentally [ 41- 43]. Figure 6B presents secondary structure diagrams of the various NaGIR2 P6a regions and their corresponding L5b loops.
As a first approach, using information on experimentally proven AuxREs, we recognized potential AuxREs in the Arabidopsis thaliana genome.
Rare monoclonal antibodies derived from naturally infected humans and from experimentally immunized animals recognize the CD4-binding site on gp120.
For instance, Cdc6-1 in S. solfataricus was experimentally proven to recognize the ORB elements of oriC1 in Halobacterium sp. NRC-1 [ 5].
Watson himself developed an early and ardent interest in cancer biology when he recognized that the experimentally tractable genomes of oncogenic viruses could provide important insights into the pathogenesis of cancer.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com