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Although we could not experimentally proof those interactions, this is an evidence for the complexity of the information flow within this pathway.
Experimentally, proof of principle studies demonstrated that inhibition of CXCL12-evoked CXCR4 signaling by respective blocking agents inhibited metastasis in experimental models, achieved by intravenous tumor cell injection [ 2426]6].
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In this context, a concept, which rests on simultaneous multi-line analysis is described and experimentally proofed.
In a first step, the freely configurable multi probe phased array was experimentally proofed in a feasibility study in close cooperation with the Fraunhofer Institute for Ceramic Technologies and Systems Dresden IKTSS).
Experimental proof on the relative weights of adhesion and cell cortex tension in controlling cell-cell contact formation in zebrafish germ layer progenitors and determining the experimentally measurable separation force between cell pairs was provided by Maître et al. (2012).
Clear experimental proof of self-medication via individual learning was recently demonstrated in domesticated sheep, which learned to ingest particular chemicals that countered toxicity from experimentally applied dietary toxins [17].
46, 4212 4220] and in this work, packed bed chemical-looping combustion was investigated experimentally to provide an experimental proof-of-principle.
In order to clarify the feasibility of rapid cycling FFAG synchrotron experimentally, a proof-of-principle (POP) machine, which accelerates protons up to 1 MeV with 1 kHz repetition, is under development.
Following our above reasoning that different lineages possess their distinct set of miRNAs, the characteristics of corresponding mRNA target sites need to be determined experimentally for final proof.
The article considers those features both theoretically and experimentally by a proof-of - the concept approach.
We experimentally verify the proof-of-principle operation of the proposed self-routing node under NRZ and OCDMA packet traffic conditions.
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