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Because the story has not been reported in the scientific literature, many virologists will read for the first time in this book about the dozen or so crab-eating monkeys who succumbed to experimentally administered smallpox virus in the summer of 2001, even before the terrorist attacks of Sept. 11 and the anthrax outbreak that followed shortly afterward.
Experimentally administered, pharmacologically effective doses of cocaine and methamphetamine may serve as a model for studying the effects of these drugs on hemodynamic response and for examining the potential utility of the antihypertensive and dihydropyridine-class calcium channel antagonist isradipine to block these effects.
For example, calves and piglets with diarrhea due to experimentally administered pathogenic E. coli were cured within 8 h following phage administration [ 16].
Feeding studies (where alcohol is experimentally administered) free of concerns about confounding may help to elucidate the mechanisms by which alcohol affects cardiovascular disease.
Experimentally administered exogenous oestrogen can protect against hypoxic PH in intact male rats and this is mediated by ERα and ERβ.
All investigators employing animals in research must assess such potential contamination because dietary agents may alter a) conclusions based on intentionally administered doses, b) outcomes by interacting with other agents that are the primary focus of the research, and c) outcomes of research unrelated to the toxic effects of experimentally administered agents.
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Since we did not assess neural activation or experimentally administer progesterone, we can only speculate about the underlying associations.
In several instances, such as rheumatoid arthritis, multiple sclerosis, and myocarditis, the autoimmune disease can be induced experimentally by administering self-antigen in the presence of adjuvant (collagen, myelin basic protein, and cardiac myosin, respectively) (3 ).
Modeling could thus be useful for helping to determine the adequate levels of ICpeptide to be administered experimentally.
Functional consequences in mammalian systems were demonstrated experimentally, as MIR168a administered in vitro and during in vivo feeding studies decreased expression of the protein product of LDLRAP1.
In other words, first, it must be experimentally elaborated whether an administered drug shows a better distribution from the outer cortex or from the capsule side towards the nephrogenic zone.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com