Their inspiration came from experimental publications like Aspen, a short-lived 1960s multimedia magazine that came in a box and counted Andy Warhol and Roland Barthes as contributors.
In recent years there have been several experimental publications describing an antifibrotic activity of silymarin upon oral application although, frequently, at doses above the therapeutic range.
These experimental publications [ 33], in our knowledge, were never confirmed by clinical studies [ 34] and not confirmed in our work.
These databases typically contain literature-derived interactions curated with different degrees of stringency, and based on experimental publications under different experimental conditions using different cell types.
Ten significant gene sets were derived from experimental publications reporting gene expression changes in cells or animal models, after treatment with 1,25(or)2D or vitamin D analogs.
Gene sets from experimental publications (12 publications provided 1 9 gene sets each) were derived from cell lines, primary cultures or xenograft mice treated with vitamin D metabolites/analogs (Table 1).
The summation effect is well characterized in multiple theoretical and experimental publications and has been extensively used for the interpretation of optically recorded action potentials in various contexts [ 20– 23].
Scientists interested in contributing can either simply supply the curators with details of key experimental publications for curation or can provide more detailed information or commentary, such as reviewing particular annotation sets and pointing out any experimental data that might be missing, wrong or controversial.
The dissociation constants calculated based on the cooperative Model 3, which also takes into account the impact of target proteins, are compared with the dissociation constants calculated using the Hill and modified Adair equation in the original experimental publications for the same data in Table 1.
The series is produced in partnership with Mossless magazine, an experimental photography publication run by Romke Hoogwaerts and Grace Leigh.
