The experimental results suggest involvement of polar interactions as well as of hydrophobic contacts in the protein recognition prior to the intermolecular electron transfer.
Compared to adults, teenagers perceived lower risk in experimental and occasional involvement in health-threatening activities [ 16].
Published experimental data support involvement of Arabidopsis homologues of NuA4 subunits YAF9 and ESA1 (Hand and HAM2) in the acetylation of lysine 5 of histone H4 [ 13].
The module incorporates genes encoding proteins, for which, to date, there is no experimental evidence of involvement in starch metabolism, for example beta-amylase At2g32290 (Band), and three phosphoglucomutase-like proteins (At4g11570, PGM-like2; At1g70730, PGM-like3 and At1g70820, PGM-like4).
Residues known to have experimental and/or predicted involvement in TAT leader/signal sequence binding (l), leader proofreading (p), co-factor insertion (c), GTP binding (g), folding stability (f), dimerization (d) and REMP motif (m) are provided below structural information.
The fact that our list of candidate genes includes genes that have strong experimental evidence of involvement in rod photoreceptor functions suggests that the other candidate genes that we have identified through our approach of using a seed network to query multiple expression datasets are worthy of careful consideration in the context of rod development.
For many important meningitis pathogens such as Neisseria meningitides (N. meningitides) [ 8], Haemophilis influenzae (H. influenzae) [ 9], Escherichia coli (E. coli) [ 10, 11], Listeria monocytogenes (L. monocytogenes) [ 11], Streptococcus suis (S. suis) [ 12] and enteroviruses [ 13], experimental data suggest involvement of the choroid plexus during bacterial entry into the brain.
With the exception of conserved sites (where there is an implicit lack of experimental evidence detailing involvement in functions, locations or processes), the above protocol currently applies to all InterPro entry types; however, some changes (detailed below) now occur for domains.
We note again that, from the clinical literature, it is well known that not only the left hemisphere but also the right can support language, and that there is even compelling experimental evidence for involvement of both hemispheres and for facilitatory hemispheric interaction in normal language processing (see above).
Since genes participate in a varied spectrum of biomolecular phenomena with a varying degree of involvement, the experimental work involves inference that admits some false positives and negatives and hence does not always necessarily yield clear-cut answers.
