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The changes in tumour volume were monitored daily until the animals reached their experimental endpoints.
Grafts were harvested at 7 days and evaluated with the experimental endpoints detailed previously.
There are no therapies for CADASIL and experimental endpoints to examine the preclinical efficacy of potential drugs are lacking.
The mouse intranasal test (MINT) was developed to assess the relative allergic potential of detergent enzymes, however, the experimental endpoints were limited to evaluation of antibody levels.
In this summary, information from published studies is used as a basis to critique clinical trial designs and to suggest experimental endpoints for future validation studies.
For the evaluation of the elimination of colorectal cancer stem cells rather than the bulk cancer cells, we used self-renewal and tumour-formation as the key experimental endpoints as such properties reflect the defining functional characteristics of the cancer stem cell population28,29,30.
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Subjects were asked if they had knowledge of and ability to detect "dry puffs," the experimental endpoint.
Both concepts are limited to cases in which all substances in a mixture influence the same experimental endpoint, and are usually tested against a "fixed ratio design" where the mixture ratio is kept constant throughout the studies and the overall concentration of the mixture is systematically varied.
The protocol for early/humane endpoints in cases where animals became severely ill prior to the experimental endpoint was implemented according to the animal facility rules.
At the experimental endpoint, the animals were euthanized with a potassium chloride injection while under deep anesthesia and disconnected from mechanical ventilation.
The LLLT and LIPUS were used to treat the area around the moving tooth once a day on days 0 7, then the experiment was ended in each experimental endpoint (1, 3, 7, 14, and 21 days).
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CEO of Professional Science Editing for Scientists @ prosciediting.com